Phthalocyanines derivatives loaded on liquid-crystal nanodispersions gel to skin cancer fluorescence diagnosis
Antonio Claudio Tedesco
Faculdade de Filosofia, Ciências e Letras (FFCLRP) – Universidade de São Paulo (USP)
Abstract:
Nanotechnology have been showed many new interesting results in the multidisciplinary fields specially as a promising candidates for improving superior biocompatibility of many drugs, and development of materials with different optical, catalytic and magnetic properties compared to conventional materials (micron structures) [1]. The development of nano drug delivery systems has improved the therapeutic and toxicological properties of existing chemotherapies and facilitated the implementation of new ones. By including the drug in technologically optimized drug delivery systems or conjugating the drugs with different polymers, it is possible to modify the pharmacokinetics and biodistribution of the drugs, improving the efficacy and security of the therapy [2]. In this context this work reports the development of new biomaterial, a nano drug delivery system to skin cancer treatment based on topical fluorescence diagnosis. Chloroaluminum phthalocyanine (ClAlPc) [chloro(29H,31H,phthalocyaninato) aluminum] was used as a fluorescence marker and photosensitizer drug loaded on liquid crystal nanodispersions gel to sustained and controlled topical release which was prepared as described by Gustafsson et al [3]. Preliminary results show that ClAlPc/gel has important photophysical and photochemical features with lifetimes and quantum yields suitable for use in the skin cancer fluorescence diagnosis in association with a semiconductor medicinal laser. Biomaterial obtained is able to use in the future studies of the cellular photobiological trials and in vitro skin release. The same platform have been used also to study many other active compounds to be used in Tissue Engineer Process and to developed drug to treat Parkinson and Alzheimer. The project was supported by governmental agency Financier of Studies and Projects (FINEP) of the Ministry of Science and Technology of Brazil.
[1] L. Zhang and T.J. Webster, Nano Today, Vol. 4, 66-80 (2009). [2] M. P. Siqueira-Moura, F. L. Primo, A.P.F. Peti and A.C. Tedesco, Pharmazie, Vol. 65, 1-6 (2010). [3] J. Gustafsson, H. Ljusberg-Wahren, M. Almgren, K. Larsson, Langmuir, Vol. 12, 4611-4613, 1996.
